Progress in Pathophysiological Mechanism of Global Cerebral Ischemia-Reperfusion Injury

Global cerebral ischemia-reperfusion injury after cardiopulmonary arrest is the majority reason for poor neurological prognosis. The pathophysiological mechanism includes endoplasmic reticulum stress (ERS), mitochondrial dysfunction, calcium overload, excessive neuro-inflammatory, platelet activation, microcirculatory thrombosis formation, delayed neurological damage, etc. All mechanisms work together to determine patients’ outcomes.