Gustatory-mediated avoidance of bacterial lipopolysaccharides via TRPA1 activation in Drosophila

An immune system can fight bacterial infections, ensuring an animal’s health and survival. However, mounting an immune response to a bacterial infection requires a lot of energy. It also can be potentially dangerous if the immune system becomes too active. Therefore, avoiding bacteria and not getting infected to begin with may be a better strategy to stay healthy. Fruit flies, like humans, can detect dangerous substances in the environment via their sense of smell, but it is not known whether they also detect disease-causing organisms through their sense of taste. Bacterial molecules called lipopolysaccharides (LPS) can alert the immune system to the presence of dangerous bacteria. Previous studies have found that when flies get in contact with LPS they begin cleaning themselves, which might help prevent infection. However it was not clear how the flies actually detected the LPS. Now, Soldano et al. show that fruit flies can taste LPS and avoid eating or laying eggs on food contaminated with LPS and bacteria. A series of experiments showed that when a fly tastes LPS it stimulates bitter-sensing neurons in the fly’s mouth and throat. The experiments also revealed that the protein that activates these neurons in response to LPS is the same protein that acts in humans as detector of pungent chemicals contained in ordinary food items like mustard, garlic and wasabi. This suggests this protein, called TRPA1, is part of a key survival mechanism that has been preserved in many species throughout evolution. Soldano et al. showed that a fly’s senses and nervous system are actively involved in protecting it from bacterial infection. This is particularly important to flies, because unlike humans they don’t develop resistance to future infections with the same bacteria. Future studies are needed to determine if flies use their sense of taste to detect other chemicals that are signs of infections. Additionally, studies are needed to determine if the activated bitter-sensing nerves alert the fly’s immune system to a potential infection.