Long-term changes in physical capacity after colorectal cancer treatment

Abstract Older patients with colorectal cancer are faced with the dilemma of choosing between the short-term risks of treatment and the long-term risks of insufficiently treated disease. In addition to treatment-related morbidity and mortality, patients may suffer from loss of physical capacity. The purpose of this review was to gather all available evidence regarding long-term changes in physical functioning and role functioning after colorectal cancer treatment, by performing a systematic Medline and Embase search. This search yielded 27 publications from 23 studies. In 16 studies addressing physical functioning after rectal cancer treatment, a median drop of 10% (range −26% to −5%) in the mean score for this item at three months. At six months, mean score was still 7% lower than baseline (range −18% to 0%) and at twelve months 5% lower (range −13% to +5%). For role functioning (i.e. ability to perform daily activities) after rectal cancer treatment, scores were −18% (range −39% to −2%), −8% (range −23% to +6%) and −5% (range −17% to +10%) respectively. Elderly patients experience the greatest and most persistent decline in self-care capacity (up to 61% at one year). This systematic review demonstrates that both physical functioning and role functioning are significantly affected by colorectal cancer surgery. Although initial losses are recovered partially during follow-up, there is a permanent loss in both aspects of physical capacity, in patients of all ages but especially in the elderly. This aspect should be included in patient counselling regarding surgery.