Lyconadins D and E, and complanadine E, new Lycopodium alkaloids from Lycopodium complanatum

Abstract Three new Lycopodium alkaloids, lyconadins D ( 1 ) and E ( 2 ), and complanadine E ( 3 ), were isolated from the club moss Lycopodium complanatum . Lyconadin D ( 1 ) was the first example of fastigiatine-type alkaloid isolated from Lycopodium complanatum . The structures and relative stereochemistry of 1 – 3 were elucidated on the basis of spectroscopic data. Complanadine E ( 3 ) enhanced mRNA expression for NGF.