Distinctive and pervasive alterations in aqueous humor protein composition following different types of glaucoma surgery

the inflow and outflow of the aqueous humor, the biologic fluid found in the anterior part of the eye. Aqueous humor is produced by the ciliary body and passes from the posterior chamber through the pupil into the anterior chamber, where the aqueous humor drains through the trabecular meshwork out of the eye into the venous system through Schlemm’s canal [1]. When aqueous inflow exceeds outflow, it may cause increased intraocular pressure that can damage the optic nerve [1]. Glaucoma is a group of diseases involving optic nerve deterioration because of increased intraocular pressure. Surgical techniques used to treat glaucoma typically rely on increasing aqueous outflow. These techniques include trabeculectomy and aqueous shunt implantation. Medicare claims data and surveys of glaucoma surgeons indicate that aqueous shunts are being increasingly used in the management of glaucoma [2].