PRIMARY ALDOSTERONISM: LC-MS/MS ASSAY FOR 24-HOUR URINE ALDOSTERONE DETERMINATION IMPROVES SCREENING

Objective:Primary aldosteronism (PA) is the first cause of endocrine hypertension accounting for about 6% of all cases of hypertension. According to international guidelines, PA screening is based on plasma aldosterone-to-renin concentration ratio (ARR) computation. Nevertheless, measurement of urin