Stereoselective Conjugate Additions to γ-Lactams: Synthesis of Polysubstituted Benzo-Fused Indolizidine Systems

The stereoselectivity of the conjugate addition of carbon nucleophiles to the bicyclic γ-lactam unit of dihydropyrrolo[2,1- a]isoquinolones depends on the nature of the nucleophile and the substituent at the angular position.