Substituted pyridinyl derivatives and methods for manufacturing the same

PURPOSE: A pharmaceutical composition containing substituted pyrimidinyl derivatives for treating metabolic disorders is provided to activate GPR119 and to treat metabolic syndrome and obesity. CONSTITUTION: A substituted pyrimidinyl derivative is denoted by chemical formula 1. In chemical formula 1, Z_1 and Z_3 are N; Z_2 and Z_4 are CH; and L_1 is O. A pharmaceutical composition for treating metabolic disorders contains the compound of chemical formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient. The metabolic disorders include type I diabetes, type II diabetes, insulin resistance, hyperlipidemis, hypercholesterolemia, and dyslipidemia.