Transportation of cefotiam from serum to lung tissue

Thirteen patients who were performed radical lobectomy for the disease of the chest, were administered of cefotiam (CTM) 1.0 g for an hour by intravenous drip infusion during their operation. The concentration of CTM in serum and lung tissue were determined. CTM showed very high concentration in lung tissue and very high concentration ratio of lung tissue to serum concentration for several hours. These results suggested that CTM will be useful agent for the prevention and treatment of pulmonary infection, since CTMsh owed also very potent antibacterial activity against Gram-positive and Gram-negative bacteria.