Efficacy Observation of Compound Sophora flavescens Injection Combined with Lamivadine on Chronic Hepatitis B Cirrhosis
2013
OBJECTIVE:To observe the therapeutic efficacy and safety of Compound Sophora flavescens injection combined with lamivadine on chronic hepatitis B cirrhosis.METHODS:75 patients with chronic hepatitis B cirrhosis in our hospital during Mar.2008-May 2010 were randomly divided into treatment group(40 cases)and control group(35 cases).Treatment group was given lamivadine 100 mg,qd orally on the basis of routine liver protection,symptomatic and supporting treatment,and intravenous dripping of 20 mL Compound S.flavescens injection added into 200 mL 0.9% Sodium chloride injection,qd.Control group received oral administration of lamivadine 100 mg,qd on the basis of routine liver protection,symptomatic and supporting treatment.A treatment course lasted for 3 months and therapeutic efficacy was evaluated after 4 treatment courses.Hepatic function index(IBIL,ALB,PT),virus activity index(qualification and quantity of HBeAg/HBeAb,HBV-DNA),hepatic fibrosis serum index(HA,LN,PCⅢ)Child-Turcotte-Pugh(CTP)grading and adverse drug reaction of 2 groups were observed before and after treatment.RESULTS:After treatment,the effective rate of treatment group(82.50%)was higher than that of control group(71.20%)(P0.05);all indexes of treatment group was better than those of control group(P0.05).11 patients in treatment group and 9 patients in control group suffered from discontinuous gastrointestinal discomfort,there was no statistical significance(P0.05).CONCLUSION:Based on routine treatment,Compound S.flavescens injection combined with lamivadine is better than lamivadine alone on chronic hepatitis B cirrhosis and improve relevant index.
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