Progress in DNA Tetrahedral Nanomaterials and Their Functionalization Research

Abstract DNA tetrahedral nanomaterials have been widely used in the fields of biosensing, drug delivery, bioimaging and separation analysis because of their high stability, good biocompatibility and easy modification. Through different designs, specific functional molecules can be modified at DNA tetrahedral vertices, DNA tetrahedral cage structures, DNA double helix structures or DNA tetrahedron arms. The advantages of the materials combine well with the specific functions of the active molecules. This paper reviewed the development of DNA nanotechnology, and introduced four different functional modifications of DNA tetrahedron nanomaterials and their research status.