Randomized Double Blind Clinical Trial Evaluating the Ellagic Acid Effects on Insulin Resistance, Oxidative Stress and Sex Hormones Levels in Women With Polycystic Ovarian Syndrome
2021
Objective: The design of this study was due to the report of the antioxidant properties of Ellagic acid (EA) for its
evaluation on the Insulin resistance (IR), oxidative stress and sex hormones levels in women with polycystic ovarian
syndrome (PCOS).
Methods: In this randomized, double-blind, placebo-controlled clinical trial, 60 patients were recruited. Patients were
randomly allocated consumed a capsule containing 200 mg of EA per day (n=30) or placebo (n=30) for 8 weeks.
The fasting blood sugar (FBS), insulin, IR, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high
density lipoprotein (HDL), total antioxidant capacity (TAC), Malondialdehyde (MDA), C-reactive protein (CRP), Tumor
necrosis factor-alpha (TNF-α), sex hormones and anti-mullerian hormone (AMH) were measured at the beginning and
end of the study.
Result: At the end of the study, the mean of FBS, insulin, IR, TC, TG, LDL, MDA, CRP, TNF-α, total testosterone, prolactin
and AMH were signifcantly decreased in the intervention group compared to the placebo group (P<0.05). Also, there
was a signifcant increase in the mean of TAC after supplementation with EA (P<0.05). At the end of the study, no
signifcant changes were observed in the mean of anthropometric factors, physical activity and food intake (P>0.05).
Conclusion: EA supplementation can be helpful as a diet supplement in women with PCOS through improvement
in insulin resistance. This supplement may be used to reduce metabolic disorders in women.
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