Outcome and Treatment of Nocardiosis after Solid Organ Transplantation: New Insights from a European Study

2017 
Background Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014. Factors associated with one-year all-cause mortality were identified using multivariable conditional logistic regression. Results One-year mortality was 10-fold higher in patients with nocardiosis (16.2%, 19/117) than in control transplant recipients (1.3%, 3/233, p<0.001). A history of tumor (odds ratio [OR] 1.4; 95% confidence interval [CI] 1.1-1.8), invasive fungal infection in the six months before nocardiosis (OR 1.3; 95%CI 1.1-1.5) and donor age (OR 1.0046; 95%CI 1.0007-1.0083) were independently associated with one-year mortality. Acute rejection in the year before nocardiosis was associated with improved survival (OR 0.85; 95%CI 0.73-0.98). Seventeen patients received short-course antibiotics (median duration 56 [24-120] days) with a one-year success rate (cured and surviving) of 88% and a 5.9% risk of relapse (median follow-up 49 [6-136] month). Conclusions One-year mortality was 10-fold higher in SOT patients with nocardiosis than in those without. Four factors, largely reflecting general medical condition rather than severity and/or management of nocardiosis, were independently associated with one-year mortality. Patients receiving short-course antibiotic treatment had good outcomes, suggesting this may be a strategy for further study.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    27
    References
    42
    Citations
    NaN
    KQI
    []