Preparation method of 1-[2-(2,4-dimethyl phenylsulfanyl)-phenyl]piperazine

The invention relates to a preparation method of 1-[2-(2,4-dimethyl phenylsulfanyl)-phenyl]piperazine. The method includes in the presence of an alkali and a catalyst, a compound II and a compound III are subjected to a reaction in an organic solvent to generate the compound I. The preparation method provided by the invention has no need of use of a palladium catalyst, and has the advantages of low cost, high yield, easy purification, and easy industrialization.