PEGylated Dimeric BODIPY Photosensitizer as Nanocarrier for Combined Chemotherapy and Cathepsin B-activated Photodynamic Therapy in 3D Tumor Spheroids

Sheng Lu,Xiang Lei,Hao Ren,Shiyue Zheng,Jian Qiang,Zhijie Zhang,Yahui Chen,Tingwen Wei,Fang Wang,Xiaoqiang Chen

PEGylated Dimeric BODIPY Photosensitizer as Nanocarrier for Combined Chemotherapy and Cathepsin B-activated Photodynamic Therapy in 3D Tumor Spheroids

2020

Sheng Lu
Xiang Lei
Hao Ren
Shiyue Zheng
Jian Qiang
Zhijie Zhang
Yahui Chen
Tingwen Wei
Fang Wang
Xiaoqiang Chen

The development of enzyme-activatable photosensitizers and their combination with conventional chemo-drugs for anti-tumor therapy are of great interest. In this work, we reported a strategy of cons...

Keywords:

tumor spheroid
Photosensitizer
Nanocarriers
combination chemotherapy
Cancer research
Photodynamic therapy
Cathepsin B
BODIPY
Chemistry

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