Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates
2011
Abstract The thiocarbamates 4-RC 6 H 4 NHC(S)NR 2 ′ (R = H, Cl; R′ = Me, Et), 4-ClC 6 H 4 NHC(S)NR (NR = 2-pyridylpiperazine) react with cis -[PtCl 2 (PTA) 2 ] (PTA = 1,3,5-triaza-7-phosphaadamantane) in the presence of base to afford the monocationic platinum(II) complexes cis -[Pt{SC(NR 2 ′) = NC 6 H 4 R}(PTA) 2 ] + (R = H, Cl; R′ = Me, Et), cis -[Pt{SC(NR) = NC 6 H 4 Cl}(PTA) 2 ] + (NR = 2-pyridylpiperazine), which were isolated as their PF 6 salts in high yields. The complexes were fully characterised spectroscopically and also by X-ray crystallography. Cytotoxicity of these complexes was studied in vitro in three human cancer cell lines (CH1, A549 and SW480) using the MTT assay.
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