Preventive effects of a few dietary nutrients against acute aluminum toxicity in mice

The efficacy of thiamine, methionine, glutathione, ascorbic acid, citric acid and zinc individually to acute aluminum-exposed mice was investigated. The ability of these compounds on blood δ-aminolevulinic acid dehydratase (ALAD) activity, glutathione level and to reduce liver, kidney and blood aluminum burden was also determined in aluminum-exposed animals. Of the 6 compounds examined, only glutathione and ascorbic acid were effective in mobilizing aluminum and reducing its lethal and biochemical effects.