artigo original Avaliação Quanto à Presença de Microalbuminúria e Hiperfiltração Glomerular no Estágio de Tolerância à Glicose Diminuída

ABSTRACT Microalbuminuria, Glomerular Hyperfiltration, and Impaired GlucoseTolerance.In the impaired glucose tolerance (IGT) phase, there are already severalcharacteristic metabolic abnormalities and risk factors in type 2 diabetesmellitus, which predispose them to develop vasculopathy. We looked forincreased urinary albumin excretion (UAE) and creatinine clearance(C Cr ) in Brazilians with IGT and normal blood pressure. The standard oralglucose tolerance test with plasma insulin was performed to classify par-ticipants into two groups: IGT and normal glucose tolerance (NGT).Overnight urine collection was used to assess the UAE (immunotur-bidimetry) and C Cr . No differences were observed between the groupsin regarding UAE and C Cr . The frequency of microalbuminuria was 21.1and 3.3% for the IGT and NGT groups, respectively (NS). In conclusion,Brazilians with IGT, normal blood pressure and insulin resistance did notpresent microalbuminuria or glomerular hyperfiltration. (Arq BrasEndocrinol Metab 2003;47/2:158-165)Keywords: Microalbuminuria; Glomerular hyperfiltration; Impaired glu-cose tolerance; Urinary albumin excretion