Matrix metalloproteinases. Part I

: Metalloproteinases (MMPs) are the extracellular matrix enzymes indispensable in physiological and pathological matrix remodeling. They are produced intracellulary as endopeptidases and secreted to the extracellular space. Under normal conditions MMPs are present in tissues at low levels which increases dramatically during any changes. To date 28 enzymes have been identified and 23 in humans. This paper is a review of metalloproteinases structure, their natural and artificial inhibitors and regulation mechanisms. Function and distribution are critical for pathogenesis and therapy of diseases.