Comprehensive evaluation of ophiopogonin enteric microsphere

AIM:To prepare ophiopogonin enteric microsphere and to carry out the comprehensive evaluation.METHODS:The microsphere was prepared by spray-drying technology,it was evaluated by common index、 enteric index and physical index.RESULTS:Yield was(81.7± 2.1)%,embedding ratio was(86.55± 0.86)%,drug loading was(23.1± 0.2)%.The drug released degree in artificial gastric juice within 2 hours was(9.18± 0.08)%.The drug released rate in artificial intestinal juice within 45 minutes was(73.79± 0.29)%.The equilibrium moisture content decreased from 12.9% to 5.8%.CONCLUSION:An comprehensive evaluation was established.