Intragenic Anaplastic Lymphoma Kinase (ALK) Rearrangements: Translocations as a Novel Mechanism of ALK Activation in Neuroblastoma Tumors

Susanne Fransson,Magnus Hansson,Kristina Ruuth,Anna Djos,Ana P. Berbegall,Niloufar Javanmardi,Jonas Abrahamsson,Ruth H. Palmer,Rosa Noguera,Bengt Hallberg,Per Kogner,Tommy Martinsson

Intragenic Anaplastic Lymphoma Kinase (ALK) Rearrangements: Translocations as a Novel Mechanism of ALK Activation in Neuroblastoma Tumors

2015

Susanne Fransson
Magnus Hansson
Kristina Ruuth
Anna Djos
Ana P. Berbegall
Niloufar Javanmardi
Jonas Abrahamsson
Ruth H. Palmer
Rosa Noguera
Bengt Hallberg
Per Kogner
Tommy Martinsson

Anaplastic lymphoma kinase (ALK) has been demonstrated to be deregulated in sporadic as well as in familiar cases of neuroblastoma (NB). Whereas ALK-fusion proteins are common in lymphoma and lung ...

Keywords:

Genetics
Neuroblastoma
Lymphoma
Biology
Medical genetics
Chromosomal translocation
Anaplastic lymphoma kinase

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