ЗНАЧЕНИЕ МОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИХ МЕТОДОВ ДИАГНОСТИКИ В ПРОФИЛАКТИКЕ ИШЕМИЧЕСКИХ ИНСУЛЬТОВ

The study was aimed at determination of importance of genetic testing data for assessing predisposition to thrombosis and the role of genetic risk factors in development of cerebral circulation disorder (CCD). The occurrence of gene polymorphisms in all components of the hemostasis system as well as the genes that determine vascular tone of patients with verified diagnosis of ischemic stroke (IS) and almost healthy individuals living in the West Siberian region were studied. It is shown that the risk of thrombotic complications is especially high at combination of mutations in genes, encoding thrombotic processes, and genes that determine the state of the fibrinolysis system and vascular tone. The state of one of the components controlling the fibrinolysis system was estimated by the content of inhibitor of plasminogen activator PAI-1 in the blood. Concentrations of PAI-1 measured in patients with ischemic stroke were significantly higher than in the blood of individuals without clinical signs of thrombophilia.. The risk of thrombosis in most patients with ischemic stroke increased significantly with a decrease in the activity of fibrinolysis system and an increase in the aggregation function of platelets. The diagnostic value of molecular-biological methods of research increases significantly at expansion of the range of DNA-polymorphisms – the markers of propensity to thrombosis. To make the decisions concerning diagnosis and tactics of selection of pathogenetically grounded methods of treatment and prevention, patient examination should be complex, including genetic testing and assessment of functional state of hemostasis and fibrinolysis systems.