Intraoperative blood glucose level changes between obese and non-obese non-diabetic patients undergoing general anaesthesia for creniotomy surgeries

Background Surgerycausesaconsiderablemetabolicstressinthenon diabeticandmoresoinadiabeticsubject Innon diabeticsubjectsthestressresponseismoreinobesepopulationthaninnon obeseduetothepresenceofinsulinresistance TheseverityofsurgeryaswellasthetypeofanesthesiainfluencesthemagnitudeofthecounterregulatoryresponseThestudywasundertakentoobservetheeffectofstressofsurgeryinobeseandnon obesenon diabeticpatientsundergoingcraniotomyundergeneralanesthesia Methods AProspectiverandomizedparallelgroupstudywasdoneonatotalof patients Theyweredividedintotwogroupsnon obesepatientsandobesepatientscomprisingof patientsineachgroupdependingontheirBMI IfatanytimeintraoperativeCBGwasfoundtobemorethanorequalto mg dLcalculateddoseofhumansolubleinsulinwasgivenasintravenousbolusequaltotheamountofCBG units Results patientsinobesepopulationdevelopedatleastoneepisodeofhyperglycemia CBG mg dL butonly innon obesepopulationdidso Insulinconsumptionwassignificantlyhigherinobesepopulationthaninnon obesepopulationtomaintainnormoglycemia Therelativeriskofbecominghyperglycemicinobesecomparedtonon obeseis CI to Conclusion Weconcludethatstressinducedhyperglycemicresponseinpatientsundergoingcraniotomysurgeryundergeneralanaesthesiaiscommoninnon diabeticobese non obesepopulation