Design of creatinine-imprinted polymers

Creatinine level in blood or urine is associated with human renal function. A high-affinity functional monomer with creatinine in preparing creatinine-imprinted polymer could be used to increase binding capacity and improve sensing with creatinine. The most absorptive functional monomer was methacrylic acid (MAA) and the functional monomer sequence was MAA>2-hydroxyethylmethacrylate (HEMA)>N-vinyl pyrrolidone (NVP)/spl Gt/4-vinyl pyridine (4VP). The selectivity of creatinine-imprinted polymer to creatine and uric acid, when MAA was used as the functional monomer, exceeded that obtained using HEMA as the functional monomer.