Sodium Thiosulfate Disposition in Humans

Thiosulfate concentrations and pharmacokinetics were studied in relation to sodium nitroprusside before, during, and after anesthesia. Normal thiosulfate concentrations were 1.13 ± 0.11 mg/dl and 0.28 ± 0.02 mg/dl in plasma and urine, respectively. Cholecystectomy patients had similar concentrations