Glioma cells with the IDH1 mutation modulate metabolic fractional flux through pyruvate carboxylase - eScholarship

Background: Over 70% of low-grade gliomas carry a heterozygous R132H mutation in the gene coding for isocitrate dehydrogenase 1 (IDH1). This confers the enzyme with the novel ability to convert a-ketoglutarate to 2-hydroxyglutarate, ultimately leading to t