Identifying symptom profiles of depression and anxiety in patients with an acute coronary syndrome using latent class and latent transition analysis.

Objective:To identify symptom profiles of depression and anxiety in patients with an acute coronary syndrome (ACS), to examine changes in symptom profiles over time, and finally, to examine the effects of age and sex on patients' symptom profiles.Methods:One hundred ACS patients with mild to severe symptoms of depression and/or anxiety at 1 month post-hospital discharge were enrolled in a randomized trial of cognitive behavioral therapy. Latent class and latent transition analyses were used to identify symptom profiles and describe change over the time in profile membership.Results:A two-class solution was selected to describe depression and anxiety symptom profiles. Class I (76% of patients at baseline) was labeled “depression and some anxiety symptoms.” Class II (24% of patients at baseline) was labeled “anxiety and some depression symptoms.” Approximately 25% of patients in the treatment condition transitioned from the depression and some anxiety symptoms class to the anxiety and some depression sympto...