Lipid Mobilizer Hormone in Cobalt Chloride Hyperlipemia

A lipid-mobilizing hormone (LM) was discovered in the plasma of man and other species by Seifter and Baeder 1 in 1954. These investigators later isolated LM from the posterior pituitary gland of hogs 2 and demonstrated that the plasma content of LM is greatly increased by the administration of cortisone and by subjecting animals to various stresses. 1,3 LM exerts two major effects: (1) it mobilizes fatty acids from the omental and mesenteric depots, and (2) it inhibits the delactescent action of heparin-clearing factor in vitro. Extensive clinical and laboratory studies have shown LM to be involved in the elevation of blood lipids which occurs consequent to surgical stress, 4,6 pregnancy, 5 and nephrosis, 1 as well as in hereditary hyperlipemias. 4 In addition, the hyperlipemias induced by protamine 7 and by diisopropyl fluorophosphate 7 appear to be mediated by the LM mechanism. This investigation was done to determine whether