The observation of concentration-response with Thresholddos Ketamine using in cesarean section

Objective To investigate the methods,the dose and the effect of ketamine with epidural anesthesia using in cesarean section.Methods All 48 pregnant women with Epidural anesthesia were randomly divided into two groups,group A of 24 cases use Midazolam 0.02 mg/kg in the first two minutes fetal childbirth,ketamine 0.4 mg/kg,iv,add the ketamine every time 0.4 mg/kg when dropping into theas needed;Group B 24 cases for intravenous administration ketamine 0.8 mg/kg,Mian fetal additional after ketamine every time 0.8 mg/kg,all drugs are auxiliary control in the first two minutes fetal newborn baby.Results All cases were safe and effective when the drug was finished,analgesic effect was good.Group A compound used Midazolam,the relatively comprehensive index is more superior: muscle loose better,less restless,on pregnancy hypertension syndrome better control,ketamine an effective dose is 0.4 mg/kg.Conclusion Using in ketamine 0.4-0.8 mg/kg of Cesarean section epidural anesthesia can make sure the puerpera fetus,safe and effective,but 0.4mg/kg,ketamine,iv,complementary with 0.02 mg/kg Midazolam application,can be in better meet the demands of the surgery at the same time,reduce the side effects in pregnant women,on pregnancy hypertension syndrome can also be used.