Multicomponent Mannich-Like Reactions of Organometallic Species

A century after the pioneering works of Carl Mannich in 1917, the aminoalkylation of carbonylated compounds has become a classical reaction of organic chemistry. Thanks to its modular character, the so-called multicomponent Mannich reaction has found numerous applications throughout the fields of chemistry, especially for synthetic and biomedical purpose. After 100 years of good service, recent developments involving nucleophile diversification through the use of stoichiometric or even catalytic amounts of organometallic species have greatly revitalized this venerable reaction and expanded its scope, thus opening the way to a new world of possibilities. This Microreview on the organometallic Mannich reaction aims to highlight seminal contributions to the field as well as the major progress recently made in this area.