Glucose detection in a highly scattering medium with diffuse photon-pair density wave

We propose a novel optical method for glucose measurement based on diffuse photon-pair density wave (DPPDW) in a multiple scattering medium (MSM) where the light scattering of photon-pair is induced by refractive index mismatch between scatters and phantom solution. Experimentally, the DPPDW propagates in MSM via a two-frequency laser (TFL) beam wherein highly correlated pairs of linear polarized photons are generated. The reduced scattering coefficient μ2s′ and absorption coefficient μ2a of DPPDW are measured simultaneously in terms of the amplitude and phase measurements of the detected heterodyne signal under arrangement at different distances between the source and detection fibers in MSM. The results show that the sensitivity of glucose detection via glucose-induced change of reduced scattering coefficient (δμ2s′) is 0.049%mM−1 in a 1% intralipid solution. In addition, the linear range of δμ2s′ vs glucose concentration implies that this DPPDW method can be used to monitor glucose concentration continuously and noninvasively subcutaneously.