Short- and Medium-Term Effects of Combined Mitral Valve Surgery and Coronary Artery Bypass Grafting Versus Coronary Artery Bypass Grafting Alone for Patients with Moderate Ischemic Mitral Regurgitation: A Meta-Analysis

Objective To investigate the short- and medium-term effects of combined mitral valve surgery (MVS) and coronary artery bypass grafting (CABG) versus CABG alone for patients with moderate ischemic mitral regurgitation (IMR). Design Meta-analysis of 4 randomized controlled trials (RCTs) and 5 observational studies. Setting Hospitals that perform cardiac surgery. Participants The study included 1,256 cardiac surgery patients from 4 RCTs and 5 observational studies. Interventions None. Measurements and Main Results Four RCTs and 5 observational studies were included in this meta-analysis. Concomitant MVS significantly reduced the residual rate of postoperative IMR (moderate or severe) (RCTs: OR –0.32, 95% confidence interval [CI] –0.58 to –0.07, p = 0.01; observational studies: OR –0.23, 95% CI –0.34 to –0.12, p Conclusions The potential benefits of combined MVS and CABG could outweigh its risks for patients with moderate IMR.