Relationship of HSPA1A +190G>C Genetic Polymorphisms with the Phenotypic indicators of Aerobic Capacity

Objective:To explore the associations between the heat shock protein 70 gene(HSPA1A)+190GC polymorphisms and the aerobic capacity to aerobic endurance training program among healthy freshmen.Methods:A total of 400 healthy freshmen were included in the present study,including 300 boys and 100 girls and all were Han nationality.All subjects performed an aerobic endurance training program of 18-week 5000m running,3 times a week with the intensity of 95%-105% aerobic threshold.VO2max,rVO2max,VE,VT and VE were measured before and after the aerobic endurance training.Polymorphisms of HSP1A1 +190GC were detected by Taqman single nucleotide polymorphism(SNP)allelic discrimination by means of an ABI7900HT.Results:The +190GC SNP in HSPA1A gene was associated with aerobic capacity in men and women,individual aerobic capacity is also increasing with the increase of the G allele.People with the HSPA1A GG genotype have lower RE/HR values,than carriers of the HSPA1A C190 allele after the endurance training(P0.05),and there was a dose response relationship among the three genotype groups(Ptrend0.05).After the endurance training the RE/HR and RE/VE values were significant reduced,and these values in GG genotype were significant lower than the C allele,and there were also dose response relationships among the three genotype groups(Ptrend0.05).Conclusion:The +190GC SNP in HSPA1A gene was not only associated with aerobic capacity but also with endurance training promotion.