ASSESSMENT AND CORRELATION OF SERUM BIOCHEMICAL PARAMETERS AND PARATHYROID HORMONE IN SELECTED ADULT POPULATION SUFFERING FROM VARIOUS STAGES OF CHRONIC KIDNEY DISEASES (CKD)

To determine correlation with biochemical and hormonal parameter, which may exist in Chronic kidney diseases (CKD) patients who are at various stages of their diseases (including renal failure and end stage renal disease-ESRD), the present study detailed the assessment of calcium, inorganic phosphorus, alkaline phospahatse, uric acid, creatinine clearance (C.C), protein to creatinine ratio (P:C ratio) and parathyroid hormone (PTH) in 57 selected patients. They were grouped as, mild CKD (n = 6); moderate CKD (n = 27); severe CKD (n = 13) and ESRD (n = 11). Estimation of biochemical parameters, PTH, creatinine clearance and protein to creatinine ratio was performed according to established procedures and techniques. The results showed that C.C. and urinary P: C ratio and plasma concentration of mean PTH was altered with high significance (P< 0.001) in severe CKD and ESRD groups as compared to mild and moderate groups. Generally all patients of mild to ESRD stages have increased level of PTH, ALP, uric acid and decline levels of calcium and C.C. Similarly a pattern of mild to moderate levels of significance (P< 0.05 to P< 0.01) was noted when biochemical parameters, P:C ratio and C.C. were compared among mild to moderate, moderate to severe and mild to severe groups, respectively. It is concluded that the selected population of patients showed altered levels of several biochemical parameters, urinary creatinine clearance, and protein to creatinine ratio and notably PTH. This established that the altered levels are directly proportional to the extent of renal failure or dysfunctions and may caused hyper-parathyroidism.