Laboratory mice and rats in biomedical research Rationale and Principles of Use

This handbook provides insight into the fundamental principles of the use of laboratory animals that must be followed in order to ethically justify their use in biomedical research, and gives a scientific, rational justification for the use of animal experimentation and its role in acquiring of new scientific knowledge, especially in the context of translational research. Its primary intent is to educate researchers responsible for directing animal experiments, but is also intended for other readers in order to help them understand the importance and the necessity of in vivo experimentation in biomedical research, as well as the specific knowledge, responsibility, persistence and awareness of persons involved in animal Research.