Relationship between leptin and lung function in young healthy children
2014
To the Editor:
Leptin, a product of the obese (ob) gene, was discovered as a hormone that plays a key role in regulating energy intake and expenditure. Over the past years, interest in the other functions of this pleiotropic hormone has increased. Leptin is primarily produced by adipocytes and is produced in lower amounts in other tissues. In the human lung, expression of leptin has been described in bronchial epithelial cells and alveolar macrophages [1]. Leptin receptors have a universal distribution that includes the respiratory system. The lung has mainly the Ob-Rb isoform, which is considered to be the fully functional receptor and most effective isoform [2]. Receptors have been identified in human bronchial and alveolar epithelial cells, bronchial smooth muscle cells, and bronchial submucosa [3]. The presence of these receptors together with evidence of local leptin production supports the concept that leptin may play a role in the regulation of airway diameter, lung development and the pathogenesis of respiratory diseases. The role of leptin in lung development has only been studied in animals and it is not known if these findings can be extended to the development of healthy human lungs. In this study we evaluated the relationship between plasma leptin levels and lung function in healthy young children and we assessed whether this relationship was modulated by the amount of adipose tissue deposits, the main source of leptin.
Participants in this study were children from the Wheezing Illness Study Leidsche Rijn (WHISTLER), an ongoing population-based birth cohort [4]. At the age of 8 years, participants were invited for a follow-up visit. During this visit, information on the child and parents was gathered by questionnaire and weight and height were measured. Spirometry was performed conforming to the latest American Thoracic Society/European …
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