Population pharmacokinetic/dynamic (PK/PD) modeling via the World Wide Web

A new research resource has been developed, allowing organizations with limited facilities for pharmacokinetic/pharmacodynamic (PK/PD) analysis to develop large and nonlinear nonparametric population models. The infrastructure described in this paper is flexible, reliable and secure. These resources are in use today by researchers in a number organizations and countries. Satellite installations continue to grow both nationally and internationally. The computational systems currently being made available through World Wide Web interfaces include the world's eighth largest supercomputer, smaller supercomputers and Beowulf systems. We first give a formulation of the problem. Then we give a description of infrastructure that is being used to overcome the problem. The last section contains an example of how the system is being used today.