Nrf2 in Immune Responses During Inflammation

One of the most studied functions of Nrf2 is its role in the maintenance of redox homeostasis in cells during oxidant stress. However, the role of Nrf2 in tissue and organism homoeostasis goes far beyond protection during oxidative conditions. In this chapter, we provide an overview of the regulation of inflammation and immune responses by Nrf2. We discuss the regulatory functions and mechanisms of action of Nrf2 on innate and adaptive immune responses, immune surveillance, and immune response in inflammatory diseases, and experimental models of disease. We also summarize the consequences of the deficiency or deregulation of Nrf2 axis and how they are related to the development and aggravation of diseases.