Dopa-responsive dystonia and hyperprolactinaemia: a novel association in two sisters

Dopa-Responsive Dystonia (DRD) is a rare hereditary condition of childhood-onset dystonia which responds dramatically to treatment with levodopa. It was first described in 1971 as a “hereditary progressive basal ganglia disease with marked diurnal fluctuation”. We describe a novel association between DRD and hyperprolactinaemia occurring in two sisters at the onset of puberty.