Flow injection spectroscopic analysis of model drugs using on-line UV-diode array, FT-infrared and 1H-nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry.
2000
A prototype flow injection analysis (FIA) system for the
characterisation of compounds via a combination of diode array UV,
1H NMR, FT-IR spectroscopy and time-of-flight (TOF) mass
spectrometry has been investigated using a number of pharmaceuticals and
related compounds as model compounds. This combination of spectrometers
allowed the on-flow collection of UV, 1H NMR, IR and mass
spectra together with atomic composition data, enabling almost complete
structural characterisation to be performed. Practical detection limits
with the current system were in the region of 50 μg, however, the use of
state of the art spectrometers would result in a significant reduction in
the amount of material required.
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