Benefits of Oral and Topical Administration of ROQUETTE Chlorella sp. on Skin Inflammation and Wound Healing in Mice
2014
The human body is constantly exposed to the risk of traumatic lesions. Chlorella is a green microalgae enriched
with nutrients, vitamins, minerals and chlorophyll. In some communities, Chlorella is a traditional medicinal plant used
for the management of inflammation-related diseases. ROQUETTE Chlorella sp. (RCs) was investigated by oral administration
(125, 250 and 500 mg/kg) and cutaneous application (2.5, 5.0 and 10.0%) to evaluate its impact in two dermatological
disorder models in mice: skin inflammation and wound healing. For skin inflammation, it was administered during
14 days starting one week before the induction of chronic skin inflammation by repeated cutaneous application of 12-Otetradecanoylphorbol
13-acetate (TPA). For wound healing the microalgae was administered by topical application after
scarification of the skin until complete wound healing. Results indicated that oral and topical administrations of the two
higher doses of RCs had significant effects on macroscopic score of skin inflammation with an efficient effect on microscopic
score with cutaneous application. The microalgae had also efficient effect on healing process and duration of
wound healing for both administration routes and particularly at the two highest doses of RCs. These findings suggest that
administration of RCs by both oral and topical routes appeared to have beneficial effects on skin lesions.
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