Role of the Lipolysis Stimulated Lipoprotein Receptor in Hepatic Lipid Homeostasis during the Postprandial Phase

Elevated postprandial lipemia (PPL) as an important risk factor for cardiovascular disease has been attributed to the accumulation of atherogenic remnant lipoproteins in the circulation. The hepatic lipolysis stimulated lipoprotein receptor, LSR, participates in the removal of these particles in the liver during the postprandial phase. LSR expression is regulated by leptin, and is reduced in obese mouse models which also display high PPL, suggesting a role of LSR in the regulation of lipid homeostasis. To determine the effect of reduced LSR expression on hepatic lipid metabolism, pathway-specific qPCR arrays were used to determine mRNA expression profiles of genes related to lipid metabolism in livers from female 6-month old LSR+/- mice and LSR+/+ littermates after 6 weeks on a standard (STD) or high-fat diet (60 % kcal, HFD). Of the 84 genes studied, 32 were significantly down-regulated in STD-LSR+/- mice as compared to STD-LSR+/+, a majority of which were involved in insulin and adipokine-signaling path...