The Changes and Its Clinical Significance of Serum Cystatin C and Urinary β2-Microglobulin Levels in Full-Term Neonates With Hyperbilirubinemia

Objective Investigate the changes of levels of serum cystatin C (CysC) and urinary β2-Microglobulin (β2-MG) in full-term neonates with hyperbilirubinemia. To explore the effect of hyperbilirubinemia on renal function in full-term neonates with hyperbilirubinemia. Methods A total of 70 full-term neonates with hyperbilirubinemia from June 2011 to June 2013 in our hospital were divided into two sub-groups:mild sub-group (n = 32) with serum bilirubin levels (220. 6 ~342. 0) μmol/L and severe subgroup (n = 38) with serum bilirubin levels more than 342. 0 μmol/L. 30 healthy full-term neonates with serum bilirubin levels less than 85. 5 μmol/L were recruited as control group. The general clinical data had no significant difference (P>0. 05). The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Central Hospital of Guangyuan. Informed consent was obtained from the parents of each participating patient. CysC were determined by processing Biology and Chemistry, β2-MG were determined by chemiluminescence immunoassay(CLIA). SPSS 13. 0 software was used to analyze the data. Results Levels of serum CysC and urinary β2-MG in the severe hyperbilirubinemia group were obviously higher than but those in severe hyperbilirubinemia group were significantly higher (P 0.05). By linear correlation analysis, there had positive correlations between the levels of the serum CysC and urinary β2-MG, serum CysC and serum bilirubin, urinary β2-MG and serum bilirubin. Conclusions Severe hyperbilirubinemia can induce renal damage in neonates. Serum CysC and urinary β2-MG can be as sensitive indicators for diagnosis of early renal dysfunction in hyperbilirubinemia. Key words: hyperbilirubinemia, neonatal; cystatin C; beta 2-microglobulin; infant, newborn