Mössbauer evidence of 57Fe3O4 based ferrofluid biodegradation in the brain

The ferrofluid, based on 57Fe isotope enriched Fe3O4 nanoparticles, was synthesized, investigated by Mossbauer spectroscopy method and injected transcranially in the ventricle of the rat brain. The comparison of the Mossbauer spectra of the initial ferrofluid and the rat brain measured in two hours and one week after the transcranial injection allows us to state that the synthesized magnetic 57Fe3O4 nanoparticles undergo intensive biodegradation in live brain and, therefore, they can be regarded as a promising target for a new method of radionuclide-free Mossbauer brachytherapy.