Synthese asymetrique d'acides amines α-disubstitues

Abstract α-Disubstituted amino acids are prepared with good optical yields by enantio-selective substitution using Schiff bases between α-monosubstituted amino acids and (S,S,S) or (R,R,R)-2-hydroxypinan-3-one as chiral reagent. The configuration of these acids is found to be dependent on the shielding effect of their aliphatic chain in the intermediary Schiff base dianion.