Clinical Characteristics and Prognostic Predictors In Hospitalized Heart Failure Patients with Improved Or Preserved Ejection Fraction

Background Clinical characteristics and prognostic predictors of hospitalized heart failure with improved ejection fraction (HFiEF) patients compared to heart failure with preserved ejection fraction (HFpEF) patients are still unclear. Methods We consecutively included hospitalized heart failure patients with left ventricular ejection fraction (LVEF) ≥40% at discharge. Patients were classified as HFiEF (documented previous LVEF Results A total of 427 HF patients (age: 64±14 years, male: 63%, HFiEF: n= 117) were enrolled. Multivariate logistic regression model suggested that patients with myocardial infarction, requiring digoxin and spironolactone at discharge, without atrial fibrillation/atrial flutter and without hyperlipidemia were associated with a diagnosis of HFiEF compared to HFpEF, with an area under the receiver operating characteristic curve of 0.805 (p Conclusion Although both presented with preserved LVEF at study baseline, hospitalized HFiEF patients have different clinical phenotype and prognosis predictors compared to HFpEF patients. Future studies are needed for differentiating between HFiEF and HFpEF without regarding previous history for optimizing targeted management.