Abstract 332: Indeterminate Troponins are Predictive of Worse Long-term Outcomes in Patients With Unstable Angina

Background: Indeterminate troponins (IT) are known to be associated with worse in-hospital and short-term clinical outcomes. However the effect of IT on long-term clinical outcomes has not been studied. Methods: We included all patients with unstable angina (USA) who underwent PCI at a tertiary multi-specialty hospital. Indeterminate and negative troponins were defined as per the troponin assay manufacturer’s recommendation. Patients were classified into indeterminate troponins (IT) group and negative troponins (NT) group. We compared long-term clinical outcomes (Death, MI, Death/MI, Target Vessel Revascularization [TVR], Major Adverse Cardiac Events [MACE- death, MI and TVR] and Stent Thromosis [ST]) between the two groups. Results: We had 94 patients in the IT group and 853 patients in the NT group. Mean follow up duration was 1422 ± 664 days. Kaplan Meier analysis showed that IT were associated with more death (p=0.0012), MI (p=0.0003), death /MI (p=0.0001) and MACE (p=0.0025) at long-term follow up. After multi-variate adjustment for all the statistically different baseline clinical and angiographic characteristics between the two groups, IT remained an independent predictor of death, MI, death/MI and MACE in long-term follow up. Conclusions: Indeterminate troponins are associated with significantly worse clinical outcomes in long-term follow up. Indeterminate troponins add incremental prognostic information in patients with USA and should be factored in risk stratification and management of these patients. ![Graphic][1] [1]: /embed/inline-graphic-1.gif