冠心病患者白介素－8与P-选择素检测的临床意义

Objectives: To study the relationship of soluble P-selectin and IL-8 with the severity of coronary artery disease (CAD), and to investigate whether they are a non-invasive marker of coronaryplaque destabilization in CAD. Methods: The 3 study groups included 50 cases of acute myocardial infarction (AMI group) within 14 hours after the onset, 50 cases of unstable angina (UAP group) within 14 hours after the last episode, 48 cases of stable angina (SAP group) and the control group consisting of 50 cases. Serum level of soluble P-selectin and IL-8 were measured by means of enzyme linked immunosorbent assay. The differences of soluble P-selectin and IL-8 levels between different groups were observed. Pearson correlation analysis test was used to analyze the relationship between the levels of soluble P-selectin and IL-8 in CAD. Results: The levels of soluble P-selectin and IL-8 were elevated in AMI, UAP and SAP groups as compared with the control group. Compared with SAP group, the levels of soluble P-selectin and IL-8 were elevated in AMI and UAP groups, while there was no significant difference between AMI and UAP groups. The levels of soluble P-selectin and IL-8 were correlated with the variation of platelet count in peripheral blood of CAD patients. Conclusion: Soluble P-selectin and IL-8 can be used as markers of the presence of coronary atherosclerosis and are involved in the pathogenesis of CAD. Measurement of them may be helpful for diagnosing coronary plaque destabilization and the severity of CAD. The levels of soluble P-selectin and IL-8 correlate with the severity of coronary artery disease (CAD).