Incidence and Associated Risk Factors of Venous Thromboembolism after Open and Laparoscopic Nephrectomy in Patients administered Short-period Thromboprophylaxis: A Danish Nationwide Population-based Cohort Study.

Abstract Objective To report the incidence of VTE after nephrectomy in Denmark and explore associated risk factors. Methods A nationwide population-based retrospective cohort study was performed. All nephrectomies from Jan 2010 to Aug 2018 were assessed for postoperative VTE events. Univariable and multivariable analyses were used to evaluate the odds ratio (OR) of clinical variables’ effect on postoperative VTEs, within four weeks and four months after nephrectomy. Results In 5213 nephrectomised patients, postoperative VTE incidence was 1% and 2% within 4 weeks and 4 months, respectively. Multivariable analyses revealed that predictors of postoperative VTE within 4 months were: open nephrectomy (OR 2.5, p=0.001), history of VTE (OR 13.3, p Conclusions For nephrectomy, postoperative VTE is rare. Open nephrectomy, history of VTE, length of hospital stay, and lymph node dissection are important risk factors which should be evaluated when tailoring VTE prophylaxis regimens.