Non-rigid Diarylmethyl Analogs of Baloxavir as CAP-Dependent Endonuclease Inhibitors of Influenza Viruses

Andrei A. Ivashchenko,Oleg D. Mitkin,Jeremy O. Jones,Alexander V. Nikitin,Angela G. Koryakova,Alexey A. Ryakhovskiy,Ruben N. Karapetian,Dmitry V. Kravchenko,Vladimir A. Aladinskiy,Irina A. Leneva,Irina N. Falynskova,Ekaterina A. Glubokova,Elena A. Govorkova,Alexandre V. Ivachtchenko

Non-rigid Diarylmethyl Analogs of Baloxavir as CAP-Dependent Endonuclease Inhibitors of Influenza Viruses

2020

Andrei A. Ivashchenko
Oleg D. Mitkin
Jeremy O. Jones
Alexander V. Nikitin
Angela G. Koryakova
Alexey A. Ryakhovskiy
Ruben N. Karapetian
Dmitry V. Kravchenko
Vladimir A. Aladinskiy
Irina A. Leneva
Irina N. Falynskova
Ekaterina A. Glubokova
Elena A. Govorkova
Alexandre V. Ivachtchenko

4-Substituted 2,4-dioxobutanoic acids inhibit influenza virus cap-dependent endonuclease (CEN) activity. Baloxavir marboxil, 4, is approved for treating influenza virus infections. We describe here...

Keywords:

Chemistry
Endonuclease
Stereochemistry

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